People in the Department

Dr Helen J Reid

Current research

Current research is focused on development of sensitive mass-spectrometric based methods for detection and quantitation of bio-molecules, including DNA-adducts, phosphopeptides and phytoestrogens. Methods are being investigated for the separation and amplification of target molecules in complex biological matrices and their detection by ICP-MS and/or organic MS. These include the use of laser ablation, hetero-atom tagging, and various chromatographic and immunoassay techniques. Also of interest is the use of chemometric methods for the interpretation of complex data sets and characterisation of materials of forensic interest.

On-Line Learning:

Investigation of innovative and flexible learning methods especially web-based learning, interactive software packages, case studies etc. Development of interactive teaching and assessment materials for on-line delivery.

Selected Publications:

S R Haider, B L Sharp, H J Reid, “Online coupling of gel electrophoresis and inductively coupled plasma-mass spectrometry”, Trends in Analytical Chemistry, 2011.  DOI 10.1016/j.trac.2011.04.025 (review article, published on-line Sept 2011) 

A Zayed, G D D Jones, H J Reid, T Shoeib, S E Taylor, A L Thomas, J P Wood,  B L Sharp, “Speciation of Oxaliplatin Adducts with DNA Nucleotides”, Metallomics, 2011, 3, 991-1000.    

S R Haider, B L Sharp, H J Reid, “A comparison of Tris-glycine and Tris-tricine buffers for the electrophoretic separation of major serum proteins”, Journal of Separation Science, 2011, 34, 2463-2467.

D N Douglas, J L Crisp, H J Reid and B L Sharp, “Laser Ablation of a Sample In Liquid—LASIL”, J. Anal. At. Spectrom., 2011, 26 (6), 1294-1301.

A Zayed, T Shoeib, S E Taylor, G D Jones, A L Thomas, J P Wood, H J Reid and B L Sharp, “Determination of Pt-DNA adducts and the sub-cellular distribution of Pt in human cancer cell lines and the leukocytes of cancer patients, following mono- or combination treatments, by inductively-coupled plasma mass spectrometry”, Int. J. Mass Spectrom., 2011, 307, 70-78

S R Haider, H J Reid and B L Sharp, “Modification of tricine-SDS-PAGE for online and offline analysis of phosphoproteins by ICP-MS”, Anal. Bioanal. Chem., 2010, 397 (2), 655-664.

H J Reid, A A Bashammakh, P S Goodall, M R Landon, C O'Connor and B L Sharp, "Determination of iodine and molybdenum in milk by quadrupole ICP-MS", Talanta, 2008, 75 (1), 189-197.

F Furno, K Morley, B Wong, B L Sharp, P L Arnold, S M Howdle, R Bayston, P D Brown, P D Winship and H J Reid, "Silver Nanoparticles and Polymeric Medical Devices: A New Approach to Prevention of Infection?", Journal of Antimicrobial Chemotherapy, 2004, 54(6), 1019-1024.

M A Dexter, H J Reid and B L Sharp, “The effect of ion energy on reactivity and species selectivity in hexapole collision/reaction cell ICP-MS”, J. Anal. At. Spectrom., 2002, 17, 676-681

M A Dexter, P K Appelblad, C P Ingle, J H Batey, H J Reid and B L Sharp, “The effect of adventitious water in hexapole collision cell inductively coupled plasma mass spectrometry”, J. Anal. At. Spectrom., 2002, 17, 183-188

C P Ingle, P K Appelblad, M A Dexter, H J Reid and B L Sharp, “The use of background ions and a multivariate approach to characterise and optimise the dominant H2-based chemistries in a hexapole collision cell used in ICP-MS”, J. Anal. At. Spectrom., 2001, 16, 1076-1084

H J Reid, “Development of web-based forensic science case studies”, Proceedings of Variety in Chemistry Teaching 2001, Royal Society of Chemistry Tertiary Education Group, 2001, p.45